Topical diphenyl diselenide mice research
WebApr 1, 2024 · Here, we addressed the pharmacology and toxicology of synthetic organoselenium compounds and some naturally occurring organoselenium amino acids. The use of selenium as a tool in organic synthesis and as a pharmacological agent goes back to the middle of the nineteenth and the beginning of the twentieth centuries. The … WebAcademia.edu is a platform for academics to share research papers. An organic selenium compound attenuates apomorphine-induced stereotypy in mice ... N. Schroder, I. Izquierdo, J.A. Henriques, R. Roesler, Differ- administration of diphenyl diselenide in mice, Neurosci. Lett. 341 (2003) ential neurobehavioral deficits induced by apomorphine and ...
Topical diphenyl diselenide mice research
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WebAug 13, 2013 · A later study of the latter research group showed that daily treatment with diphenyl diselenide (5 lmol/kg) prevented MeHg-induced brain mitochondrial dysfunction, … WebJan 1, 2024 · The current study investigated the effect of organoselenium compound p,p′-methoxyl-diphenyl diselenide [(OMePhSe) 2], free or incorporated into nanocapsules, on behavioral, biochemical and molecular alterations in an inflammatory pain model induced by complete Freund's adjuvant (CFA). Male Swiss mice received an intraplantar injection of …
WebDiphenyl diselenide is used in the methoxyselenenylation of alkenes, dihydroxylation of double bonds, hydrothiolation of terminal alkynes. It is used in the synthesis of the … WebObjectives: This study investigated the involvement of different types of K(+) channels and PPARgamma receptors in the antidepressant-like effect of diphenyl diselenide in mice. Methods: Mice were pretreated with subeffective doses of K(+) channel inhibitors (tetraethylammonium, glibenclamide, charybdotoxin and apamin), openers (cromakalim, …
WebAug 13, 2013 · A later study of the latter research group showed that daily treatment with diphenyl diselenide (5 lmol/kg) prevented MeHg-induced brain mitochondrial dysfunction, oxidative stress and reduction ...
WebSep 1, 2010 · The results suggest that (PhSe)2 may be useful for the treatment of cognitive impairment that may hold significant therapeutic value in alleviating certain memory deficits observed in Alzheimer's disease. This study was conducted to evaluate the effects of exposure to diphenyl diselenide (PhSe)2 on cognitive impairment induced by …
WebBisphenol A (BPA) is a chemical toxicant that has deleterious effects on human. BPA causes oxidative stress in tissues, including the liver. Diphenyl diselenide (PhSe) 2 improves the antioxidant response via activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like ECH-associated protein (keap 1) pathway in macrophage cells. In the … ptef traneWebAbstract. In the current study, nanocapsules (NC) formulations containing a co-load of clotrimazole (C), a highly prescribed antifungal drug, and diphenyl diselenide [(PhSe) 2], an organoselenium compound with a promising scope of pharmacological actions, were prepared.Formulations were characterized as well as the potential toxicity, antioxidant … hotchkiss facilitiesWebDec 11, 2013 · The acute liver failure (ALF) induced by acetaminophen (APAP) is closely related to oxidative damage and depletion of hepatic glutathione, consequently changes in cell energy metabolism and mitochondrial dysfunction have been observed after APAP overdose. Diphenyl diselenide [(PhSe)2], a simple organoselenium compound with … hotchkiss flat oval pricesWebDiphenyl diselenide (Ph 2 Se 2) is an organoselenium compound.Its crystalline structure,[] toxicokinetic properties,[] antioxidant and anti-inflammatory activities have been investigated.[] Its ability to reverse the oxidative brain damage and mitochondrial dysfunction induced by acetaminophen has been studied in mice.[] It reacts with thallium … ptech texasWebFeb 1, 2003 · Administration of 200 μmol/kg diphenyl diselenide (i.p.) induced 100% seizures in mice and caused 50% death in 72 h. All mice died after doses higher than 350 … hotchkiss flower farmWebFeb 1, 2003 · Administration of 200 μmol/kg diphenyl diselenide (i.p.) induced 100% seizures in mice and caused 50% death in 72 h. All mice died after doses higher than 350 μmol/kg of diphenyl diselenide. At lower doses (25–150 μmol/kg), no seizures were observed. The LD 50 calculated and the 95% confident interval was 210 μmol/kg … ptee filterWebDiphenyl diselenide-modulation of macrophage activation: Down-regulation of classical and alternative activation markers Lucı´a L Rupil1,2, Andreza F de Bem2 and German A Roth1 Abstract Diphenyl diselenide (PhSe) 2, a simple organoselenium compound, possesses interesting pharmacological properties that are under extensive research. hotchkiss flower shop