Irf6 cancer
WebApr 19, 2024 · IRF6 is downregulated in high-staged bladder cancer patients Finally, we examined expression and promoter methylation of IRF6 in TCGA bladder cancer cohort. … WebMay 3, 2024 · Inhibition of KIF20A by transcription factor IRF6 affects the progression of renal clear cell carcinoma Abstract. Renal clear cell carcinoma (ccRCC) is one of the most …
Irf6 cancer
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WebApr 19, 2024 · Several genes, including IRF6 (interferon regulator factor 6), showed an upregulation after CPH treatment. We therein demonstrated that IRF6, a potential tumor suppressor, is epigenetically silenced by DNA methylation and histone modifications in UC. Restoration of IRF6 expression by CPH may be a novel therapeutic strategy in the … WebSep 1, 2024 · IRF6 is initially found to be down regulated in our well established high-metastasis NPC cellular clone, and further series functional studies confirmed that IRF6 can inhibit the growth, migration, invasion, and metastasis of NPC cells. • Elevated IRF6 expression can enhance NPC chemotherapeutic sensitivity. •
WebBackground:Emerging evidence have indicated that IRF6, as a member of the Interferon regulatory s factors (IRFs) family, plays important roles in a variety of tumors. However, the expression status of IRF6 and its prognostic value in clear cell renal cell carcinoma (ccRCC) remain unclear.
WebIndeed, we observed that a small molecule proteasome inhibitor bortezomib used for multiple myeloma treatment [32] upregulates both IRF6 and its target BLNK in ErbB2-positive breast cancer cells ... Web• Identified two novel clinically relevant biomarkers (IRF6 and PERP) of HER2 targeted therapies such as trastuzumab and lapatinib used for breast cancer treatment by using flow cytometry ...
WebJun 21, 2024 · Conversely, IRF6 is upregulated in poorly aggressive breast cancer cells. Functional studies revealed that elevated IRF6 expression suppressed cell proliferation and the tumorigenicity, enhanced cell chemotherapeutic sensitivity. Therefore, our findings suggest that IRF6 is a viable therapeutic target in breast cancer.
WebJun 11, 2024 · Lin28A promotes IRF6-regulated aerobic glycolysis in glioma cells by stabilizing SNHG14 - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. pop up weddings tasmaniaWebThe IRF6 gene provides instructions for making a protein that plays an important role in early development. This protein is a transcription factor, which means that it attaches (binds) to … sharon powers facebookWebJul 10, 2015 · IRF6, a member of Interferon Regulatory Factors (IRF) family, is involved in orofacial and epidermal development. In breast cancer cell lines ectopic expression of … pop up wedding invitation cardsWebIRF6 is a transcription factor that belongs to a family of nine transcription factors that share a highly conserved helix-turn-helix DNA-binding domain and a less conserved protein-binding domain. Most IRFs regulate the expression of interferon-alpha and -beta after viral infection, but the function of IRF6 is related to epidermal development. – sharon power actressWebGenetic ablation of Ripk4 or Irf6 in mice leads to similar skin, limb, and craniofacial defects associated with epidermal hyperplasia, parakeratosis, and soft tissue fusions, as observed in humans, suggesting that the mouse models are relevant to the human disease processes [ … pop up weddingsWebThe interferon regulatory factor 6 (IRF6) is functioned as a tumor suppressor gene in several cancers and is associated with risk of CRC. We explored the role of IRF6 in CRC in the present... sharon powers coloradoWebIRF6 INFORMATION. Proteini. Full gene name according to HGNC. Interferon regulatory factor 6. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. IRF6 (LPS, OFC6, VWS, VWS1) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). pop up wedding tent 20x30