Hif glut1
Web16 de jun. de 2024 · Down-regulation of miR-34a significantly promoted GLUT1 expression. Knockdown of GLUT1 reduced the glycogen content in GIFT liver cells, inhibited HIF-1a gene expression, up-regulated the expression of genes involved in P53 signaling pathways (P53 and CASPASE-3 genes), and accelerated hepatocyte apoptosis under hypoxia stress. Web13 de nov. de 2024 · Cancer, the main cause of human deaths in the modern world is a group of diseases. Anticancer drug discovery is a challenge for scientists because of involvement of multiple survival pathways of cancer cells. An extensive study on the regulation of each step of these pathways may help find a potential cancer target. Up …
Hif glut1
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WebHypoxia-inducible factor (HIF) is a sensor of hypoxia and a regulator of the cellular hypoxic response. HIF is a heterodimeric complex comprised of an α-subunit, usually HIF-1α, and a β-subunit, usually the aryl hydrocarbon receptor nuclear translocator (ARNT). Under normoxic conditions HIF-1α is polyubiquitylated and targeted for ... Web14 de ago. de 2001 · While the studies reported herein were being completed, Ivan et al. and Jaakkola et al. reported that mammalian cell lysates can hydroxylate HIF-1α at Pro-564 in vitro, which in turn promotes VHL binding.Although the HIF-1α prolyl hydroxylase has not yet been identified, this finding suggests that under hypoxic conditions, the regulated …
Web18 de mar. de 2024 · HIF-1a was stabilised by 4 and 6 h OGD in PC12 cells and 2 h OGD onwards in primary neurons. A panel of hypoxic genes were upregulated by the OGD treatments depending on the duration. ... Glut1 was significantly upregulated by 4 h (~17-fold), 6 h (~21-fold), and 12 h (~25-fold) of OGD. Web12 de dez. de 2014 · Hypoxia inducible factor (HIF) is responsible for the transcription activation of a number of glycolytic genes as well as GLUT1 . Results of epidemiological studies indicate that obesity and diabetes are associated with an increased risk of several types of cancer, including colonic, esophageal, gastric, liver, pancreatic, kidney, …
Webglut1gene expression and glucose transport are also stimulated in a variety of cells under hypoxic conditions, a response that is mediated by the transcription factor HIF-1. 1 HIF-1 … Web15 de jan. de 2024 · Quantitative RT-PCR expression of HIF-1 targets Glut1 (D) and VEGF (E) in primary pericytes isolated from SMMHC-CreERT2; HIF-1α fl/fl mice and treated with 2 µM tamoxifen (LoF, loss of function) compared to hypoxic vehicle controls (oil, Ctrl) after 48 h hypoxic exposure (1% O 2).
Web目的 探讨缺氧诱导因子-1 α(HIF-1 α)对缺氧状态下血管内皮细胞的保护机制. 方法 ①建立小鼠失血性休克模型,选取休克组与假手术组(n=3)血管内皮细胞,进行转录组测序,分析主要差异基因.②检测对照组(正常培养)与缺氧组(缺氧培养6h)(n=3)中人脐静脉内皮细胞(HUVECs)的HIF-1α及葡萄糖转运蛋白1(GLUT1)的表达 ...
Web8 de set. de 2024 · Orexin A stimulated GLUT1 expression, glucose uptake as well as ATP generation in HepG2 cells via OX1R acting through the HIF-1α pathway. Moreover, orexin A inhibited LDHA, PDK1 expression and lactate production, stimulated PDHB expression and PDH enzyme activity independent of HIF-1α. leafy meansWeb13 de mar. de 2024 · Previous reports demonstrated that HIF-1α regulated glucose metabolism through activating its downstream factor Glut1 [24, 25], which also played an important role in ovarian granulosa cells . Similarly, we found that the expression pattern of Glut1 was significantly upregulated (Figure 2G ); knockdown of Hif-1a downregulates … leafy lightsWebDuring early pregnancy, placentation occurs in a relatively hypoxic environment that is essential for appropriate embryonic development, and GLUT1 expression is enhanced in … leafy love affair opening hoursWeb28 de fev. de 2014 · In AML patients, high expression levels of HIF-1α and GLUT1 were associated with lack of response to chemotherapy, probably due to the higher glycolytic metabolism of resistant tumor cells [125]. leafy mugen downloadWeb18 de nov. de 2013 · To reconfirm the importance of HIF to tumor growth in a xenograft model, the expression of HIF1β protein in 786-O cells was stably suppressed by an … leafy love affair tampaWebGLUT 1. O transportador de glicose 1 (ou GLUT1) é uma proteína de membrana composta por 492 resíduos de aminoácidos, a qual é codificada nos humanos pelo gene SLC2A1. … leafy love affairWeb29 de ago. de 2014 · In mammalian cells hypoxia stimulates Glut1 expression and glucose transport [8, 57, 58] and the Glut1 promoter has hypoxia response elements recognized by HIF-1 (hypoxia inducible factor 1) . The GLUT1 regulation by hypoxia has not been reported in crustaceans but, it is well known that in L. vannamei hypoxia induces a shift from … leafy life