WebConnective tissue growth factor acts as an important downstream effector of TGF-β1/PI3K signalling pathway to promote ECM production during pulmonary fibrosis. PI3K inhibitor prevented pulmonary fibrosis from lung epithelial cells by reversing EMT and down-regulation of CTGF and collagen I. WebDec 1, 2024 · Connective tissue growth factor (CTGF), also known as cellular communication network factor 2 (CCN2), is one of the most widely studied members of the CCN family. CTGF is highly expressed in many ...
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WebMar 4, 2024 · Connective tissue growth factor (CTGF), ... Summing up, we found that TGF-β promoted FGF-2 expression, triggered FGF receptor subtype b to c transition via CTGF, and promoted EMT in AE2 cells. Therefore, msFGFR2c could inhibit the promoting effects of TGF-β, CTGF, and FGF-2 during lung fibrosis and has the potent clinical value … WebMay 28, 2009 · We and others have shown that hepatocytes substantially synthesize connective tissue growth factor (CTGF/CCN2) during culture and in injured liver and are likely to be the major cellular source of CTGF in the liver. 1, 2 CTGF is a 36- to 38-kDa, cysteine-rich, heparin-binding and secreted protein that was first identified in the …
WebSep 1, 2007 · TGF-β and EMT. TGF-β is a multifunctional cytokine that regulates tissue morphogenesis and differentiation through effects on cell proliferation, differentiation, apoptosis, and extracellular matrix production ().TGF-β has been implicated as a “master switch” in induction of fibrosis in many tissues including the lung ().In this regard, TGF-β … WebFeb 7, 2024 · The epithelial–mesenchymal transition (EMT) is a phenomenon in which epithelial cells differentiate into mesenchymal cells and is widely recognized as a mechanism of malignant transformation of cancer, in which epithelial-derived cancer cells acquire migratory properties and invade blood vessels. ... Fn1, and Ctgf. HUVECs …
WebJun 1, 2024 · Increasing evidence indicates that connective tissue growth factor (CTGF), a multifunctional signaling modulator, promotes cancer initiation, progression, and … WebMay 15, 2013 · Furthermore, expression of CTGF in lung epithelial cells or treatment with exogenous CTGF also induced EMT-like changes in vitro. Overall, our results provide …
WebSep 9, 2015 · Expression of CTGF highly correlates to EMT markers. EMT is a fundamental process in organ fibrosis and has been demonstrated to be closely related to cancer progression . To see whether CTGF has any connection with EMT, we first performed a co-expression analysis between CTGF and EMT markers in clinical breast tumors and a …
WebSep 17, 2024 · EMT is the process by which epithelial cells lose their original phenotype and develop the mesenchymal phenotype during embryonic development, 12 fibrogenesis, 13 wound healing, 14 or cancer metastasis. 15, 16 In adults, EMT promotes pathological conditions such as organ fibrosis 17 and tumour metastasis. The most common … birmingham new street to glee clubWebJun 18, 2024 · Oral submucosal fibrosis (OSF) is a premalignant disorder of the oral cavity, and areca nut chewing is known to be a major etiological factor that could induce epithelial to mesenchymal transition (EMT) and activate buccal mucosal fibroblasts (BMFs). However, this detailed mechanism is not fully understood. In this study, we showed that the … birmingham new street to iccWebOct 29, 2024 · Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved in different biological processes, such as cell proliferation, angiogenesis, and wound healing, as well as multiple … birmingham new street to digbeth stationWebJun 8, 2024 · Endothelial-to-mesenchymal transition (EMT) and angiogenesis play important roles in colorectal cancer (CRC) development. Connective tissue growth factor (CTGF) has been reported to promote several kinds of cancer progression and miR-218 has been identified as a tumor suppressor miRNA. However, little is known about the function of … danger of fluoride in toothpasteWebCTGF and β-catenin are involved in the EMT of podocytes in diabetes. CTGF mediates high-glucose induced EMT through activation of β-catenin in podocytes. CTGF inhibition … birmingham new street to hippodromeWebConnective tissue growth factor (CTGF), also termed fisp12, β IG-M2, and IGF-BP8, is a secreted cysteine-rich growth factor that belongs to the CCN (cyr61, CTGF, nov) family. It was first isolated in 1991 from serum-stimulated NIH3T3 cells and named fisp12 (fibroblast-inducible secreted protein-12). The term ‘connective tissue growth factor ... danger of frozen waterWebmine the relation of miR-218 and CTGF. R: miR-218 was down-regulated in CRC cell lines and over expression of miR-218 could significantly inhibit EMT and angiogenesis. CTGF was a direct target of miR-218. Up regulation of CTGF level after miR-218 transfection could sufficiently rescue the suppression effects on EMT and angiogenesis. birmingham new street to holiday inn b5 4ew