Cisplatin transporter

WebApr 26, 2024 · Full article: Update on drug-drug interaction at organic cation transporters: mechanisms, clinical impact, and proposal for advanced in vitro testing Expert Opinion on Drug Metabolism & Toxicology Volume 17, 2024 - Issue 6 Open access 2,926 Views 2 CrossRef citations to date 0 Altmetric Listen Review WebCisplatin is mainly internalised by the copper transporter CTR1. Accordingly, CTR1 down-regulation has been associated with resistance to platinum-based drugs in cancer [ 10 , 11 ]. Cellular inactivation of cisplatin and subsequent sequestration can be mediated by binding to cytoplasmic nucleophilic factors, including glutathione (GSH) and ...

The Mechanotransduction Channel and Organic Cation Transporter …

WebMay 17, 2024 · They postulated that cisplatin could compete with copper for CTR1-mediated transport, but did not further investigate the consequences on copper homeostasis or potential modification of CTR1. Platinum coordination may also alter conformation or block necessary amino acids for native Cu (I) interactions. WebCisplatin is both a substrate and inhibitor of OCT2 transport, and its accumulation and renal cytotoxicity has been demonstrated to be a consequence of the overexpression of OCT2 in human and rat proximal tubular epithelial cells (PTECs) ( Yonezawa et al., 2006 ). bing quizzes football 1996 https://hotel-rimskimost.com

Cisplatin (Cisplatin Injection): Uses, Dosage, Side Effects ... - RxList

WebApr 24, 2015 · Cisplatin seems to interact preferentially with hOCT2 (Ciarimboli et al., 2005), suggesting that hOCT2 is the critical transporter for renal cisplatin uptake in … WebCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, ... membrane-bound mechanosensitive sodium … WebFeb 28, 2024 · However, the principal mechanisms by which 13 and, above all, 18 overcome cisplatin resistance rely on three different possible mechanisms: the inhibition of endogenous P-gp expression, a transporter that enables the active efflux of the drug from the cancer cells; the generation of ROS inside the cells that can reduce GSH levels, a … bing quizzes daily 2014

Contribution of organic cation transporter 2 (OCT2) to cisplatin ...

Category:Cisplatin nephrotoxicity: a review of the literature

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Cisplatin transporter

Cisplatin nephrotoxicity: a review of the literature - PubMed

WebThe direction of MATE1 transport is defined by the proton concentration gradient: when assayed in vitro at pH 7.4 or higher, MATE1 behaves as an uptake transporter, whereas … WebMay 11, 2012 · Cisplatin is a prescription medicine used alone to treat bladder and ovarian cancer.It is also used together with other drugs to help treat testicular cancer, locally …

Cisplatin transporter

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WebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the development of AKI in patients with DM. MATE1/SLC47A1, an organic cation transporter in proximal tubular epithelial cells, mediates the tubular secretion of cationic drugs or … WebNov 15, 2024 · Magnesium co-administration decreases cisplatin-induced nephrotoxicity in the multiple cisplatin administration Life Sci. 2024 Nov 15;189:18-22. doi: 10.1016/j ... Expression of renal organic cation transporter 2 (rOct2) and multidrug and toxin extrusion protein 1 (rMate1), which are involved in CDDP transport, did not differ between the …

Webwww.ncbi.nlm.nih.gov WebThese transporters have a large binding site containing partially overlapping interaction domains for different substrates and are specifically distributed around the body. …

WebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the … WebCisplatin triggers rapid degradation of Copper Transporter 1, reducing influx of cisplatin and increasing resistance to it. Explore the transporter in PDB ID 6m97 . Glutathione transferase (GST) P1-1 is a cisplatin-binding protein that can inactivate cisplatin.

WebFeb 23, 2007 · Ctr1, the major copper influx transporter, has been convincingly demonstrated to transport cisplatin and its analogues, carboplatin, and oxaliplatin. Evidence also suggests that the two copper efflux transporters ATP7A and …

WebDec 14, 2024 · Cisplatin (CDDP) is a chemotherapy drug commonly used in systemic treatment of germ cell tumors, including cancers of the ovaries, testes, and solid tumors of the head and neck 1. d5w iv pushWebIn addition, cisplatin is the standard treatment of patients with non-small cell lung cancer (NSCLC) when druggable mutations are not present in the tumour 34. Hence, Pt drugs have not been... d5w medical definitionWebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … d5w maintenance fluid hypoglycemiaWebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … d5w nursingWebCisplatin, or cis-diamminedichloridoplatinum(II) cis-[PtCl 2 (NH 3) 2], is a platinum-based anticancer drug largely used for the treatment of various types of cancers, including … bing quizzes football 1998WebMar 20, 2024 · Cisplatin is a substrate of hOCT1 ( SLC22A1 ), hOCT2 ( SLC22A2 ), and hMATE1 ( SLC47A1 ), and oxaliplatin is a substrate of hOCT2, hOCT3 ( SLC22A3 ), hMATE1 ( SLC47A1 ), and hMATE2-K ( … d5w med cardWebApr 14, 2024 · HIGHLIGHTS. who: ICP-TOF et al. from the Autonomous University of Madrid, Spain have published the research: The copper transporter CTR1 and cisplatin accumulation at the single-cell level by LA-ICP-TOFMS, in the Journal: (JOURNAL) what: In this study, total CTR1 levels (comprising plasma_membrane-associated and intracellular … d5w lactated ringers