Cisplatin nmr
WebApr 1, 2014 · 1 H and 13 C NMR spectra were recorded on a Bruker AV 400 NMR spectrometer in DMSO-d 6. Fourier transform infrared (FT-IR) spectra were recorded on a Bio-Rad Win-IR instrument using KBr method. ... Moreover, cisplatin crosslinking could largely enhance micellar stability and might effectively prevent premature drug release … WebFeb 9, 2001 · Our studies on STEALTH cisplatin show that NMR is a powerful tool in the characterization of drug-lipid interactions, the physical state of the drug inside the …
Cisplatin nmr
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WebIn this paper we illustrate how NMR spectroscopy can provide new insights into the mechanism of action of platinum anticancer drugs, including the detection of intermediates in DNA platination reactions and metabolites in body fluids. ... J.D. Ranford and P.J. Sadler, Hydrolysis products of cisplatin: pK a determinations via [1 H, 15 N] NMR ... WebIntroduction. Cisplatin (cis-diamminedichloroplatinum(II)) is one of the most widely used first-line chemotherapeutic agents for a broad range of cancers.Cisplatin continues to be in widespread clinical use for various solid tumors such as ovarian, testicular, bladder, head and neck, and non-small cell lung cancers 1,2 but its usefulness is limited due to its high …
WebNov 30, 2024 · Doxorubicin, cisplatin, and tamoxifen are part of many chemotherapeutic regimens. However, studies investigating the effect of chemotherapy on the metabolism of breast cancer cells are still limited. We used 1H high-resolution magic angle spinning (HR-MAS) NMR spectroscopy to study the me … WebSep 19, 2009 · Cisplatin [ cis -diamminedichloridoplatinum (II)] is used in chemotherapy where platinum–DNA adducts initiate tumor cell death. It is possible that side effects such as neurotoxicity and cellular cisplatin resistance can be due to interaction of cisplatin with lipids and the phospholipid bilayer.
WebNov 9, 2006 · The direct detection of 195Pt- and 15N-NMR signals was widely used in early studies of reactions of cis-diamminedichloroplatinum (II) (cis-DDP) with various … WebMay 1, 2024 · The equilibrium structures of cisplatin and transplatin were optimized, and their 1 H, 15 N, and 195 Pt NMR chemical shifts were evaluated at both non-relativistic and fully relativistic four-component levels. Reliable correlations with experimental data were achieved at the DFT level with taking into account relativistic effects in calculations of …
WebMay 1, 2024 · Geometries and NMR properties of cisplatin and transplatin revisited at the four-component relativistic level. The equilibrium structures of cisplatin and transplatin …
WebApr 9, 1999 · NMR studies of the activation of cisplatin and related complexes, DNA platination, reactions with amino acids, peptides and proteins are discussed in this … diabetic syringe magnifierWebCisplatin (CP) is an anti-cancer drug used for treatment of solid tumors, but the major adverse effect is drug-induced nephrotoxicity. The current study aimed to determine … cinemark food prices 2021WebOct 22, 2024 · In NMR analysis, the effect of C. nutans aqueous extract against cisplatin on NRK-52E was quantitatively determined relative to the concentration of the internal reference standard, trimethylsilyl propionic acid (TSP). The concentration of the metabolites in NRK-52E cells extract and culture media of treated and non-treated groups and their ... cinemark foreign credit cardsWebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes … cinemark food and drinkWebThe paper gives an overview of the basic NMR techniques particularly relevant for studying interaction between platinum compounds and nucleic acid constituents. The latest NMR … diabetic tabletkiWeb195Pt and 15N nuclear magnetic resonance (NMR) was used to study the chemical equilibria of cisplatin in water and plasma ultrafiltrate (PUF). Cisplatin was found to be … diabetic tachycardiaWebAug 6, 2015 · Cisplatin rapidly accumulates in mitochondria and deteriorates the mitochondrial structure and metabolic function [ 13 ]. This leads to significant changes in the metabolites level related to the tricarboxylic acid cycle (TCA cycle) and glycolysis pathway [ … cinemark folsom showtimes