Cisplatin nephropathy

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August undefined, 2024

WebMay 1, 2008 · Cisplatin is one of the most widely used and most potent chemotherapy drugs. However, side effects in normal tissues and organs, notably nephrotoxicity leading to tubular and inflammation. Renoprotective approaches are being discovered, but the protective effects are mostly partial, suggesting the need for combinatorial strategies. WebCisplatin is a platinum containing drug first approved as an antineoplastic agent in 1978. It remains an important and effective therapy in many forms of cancer today. Cisplatin …

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WebIn order to confirm the additional adverse effects of KU55933 on cisplatin-induced DNA damage and to elucidate the For all groups, data are means ± SEM, *p < 0.05 vs control, # p < 0.05 vs ... WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … chilling adventures of sabrina cast abigail

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WebApr 12, 2024 · Cisplatin is a highly effective anti-cancer agent used in the treatment of solid organ tumors, such as head and neck, lung, breast, testis, and ovarian cancers 1, 2. Although cisplatin has... WebCisplatin chemotherapy and surgery are effective treatments for children with standard-risk hepatoblastoma but may cause considerable and irreversible hearing loss. This trial WebJul 22, 2024 · Cisplatin nephropathy is a representative chemotherapeutic agent-related AKI. The molecular mechanisms underlying cisplatin-induced AKI have long been the subjects of research, and a number of studies have demonstrated the involvement of mitochondrial dysfunction, oxidative stress, inflammation, and apoptosis in renal tubular … chilling adventures of sabrina cast 3 sisters

Effect of Cisplatin on Renal Iron Homeostasis Components: …

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WebCisplatin ATN AKI, hypomagnesemia, renal sodium Chronic interstitial ﬁbrosis and cyst formation wasting, CKD Ifosfamide ATN Fanconi syndrome (partial or complete) AKI ESRD Methotrexate Crystal nephropathy Nonoliguric AKI Pemetrexed ATN AKI AIN CKD Tubular atrophy and interstitial ﬁbrosis Nephrogenic diabetes insipidus Ipilimumab AIN AKI WebSep 15, 2008 · Cisplatin (Platinol) Chronic interstitial nephritis, tubular cell toxicity: Interferon-alfa (Intron A) Glomerulonephritis: Methotrexate: Crystal nephropathy: … chilling adventures of sabrina billyWebDec 21, 2024 · Previous publications have revealed that NOX4 overexpression exacerbated tubular damages in diabetic nephropathy , ischemia/reperfusion- or cisplatin-induced AKI [37,39], obstructive nephropathy , and hypertensive nephropathy . Thus, NOX4 can be up-regulated in various scenarios, which might be dependent upon its transcriptional or post ... grace lochner fort wayne

"WebApr 12, 2024 · In recent years, the onco-nephrology field has acquired a relevant role in internal medicine due to the growing number of cases of renal dysfunction that have been observed in cancer patients. This clinical complication can be induced by the tumor itself (for example, due to obstructive phenomena affecting the excretory tract or by neoplastic … " - Cisplatin nephropathy

Cisplatin nephropathy

Renal tubular injury exacerbated by vasohibin-1 deficiency in a …

WebSide effect and toxicity management Prophylaxis and treatment Prevention and management of cisplatin nephrotoxicity ID: 184 v.3 Endorsed This document is an … WebNational Center for Biotechnology Information

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WebMar 22, 2024 · They exert their main toxic effect within the tubular cell by altering phospholipid metabolism. In addition to their direct effect on cells, aminoglycosides cause renal vasoconstriction. The 2... WebSep 15, 2008 · In thrombotic microangiopathy, organ damage is caused by platelet thrombi in the microcirculation, as in thrombotic thrombocytopenic purpura. 30 Mechanisms of renal injury secondary to drug-induced...

WebOct 22, 2024 · Cisplatin is a commonly used anticancer drug, but nephrotoxicity is a dose-limiting adverse effect. Recent experimental and clinical observations have demonstrated that multiple injections of... WebCisplatin is an important chemotherapeutic drug for the treatment of solid tumors but often causes nephropathy as part of the off-target toxicity. Iron accumulation and related damage were implicated in cisplatin-induced kidney injury.

WebKidney disease, or renal disease, technically referred to as nephropathy, is damage to or disease of a kidney. Nephritis is an inflammatory kidney disease and has several types according to the location of the inflammation. Inflammation can be diagnosed by blood tests. Nephrosis is non-inflammatory kidney disease. WebOct 1, 2024 · We identified Compound-6c(Cpd-6c) as having the best activity and examined its protective effect against cisplatin nephropathy both in vivo and in vitro in cisplatin-stimulated tubular epithelial cells (TECs). Our results showed that Cpd-6c restored renal function more effectively than Ru, as evidenced by reduced blood urea nitrogen and …

WebFeb 2, 2024 · 5.1 Cisplatin-Induced Nephrotoxicity. Cisplatin, ... Let us pay attention to whether, the body affected by nephropathy also causes further nephrotoxicity by breaking the balanced relationship between the two pathways, in addition to nephrotoxicity caused by the crosstalk of Nrf2 and NF-κB. When exploring whether diabetes aggravates I/R …

chilling adventures of sabrina cast susieWebOct 13, 2024 · Cisplatin is nephrotoxin that can cause both acute kidney injury and chronic kidney disease. Accumulation of cisplatin in renal tubular cells induces various intracellular stresses, including... chilling adventures of sabrina cast agathaWebCisplatin-nephropathy model mice exhibited elevated levels of serum IS accompanied by elevated levels of blood urea nitrogen and serum creatinine. Furthermore, intraperitoneal administration of IS in mice promoted tumor growth and metastasis. Finally, we found that the MasR agonist Ang-(1-7) suppressed the IS-mediated effects on cell ... chilling adventures of sabrina cast season 4WebOct 6, 2016 · Cisplatin [Cis-diamminedichloroplatinum (II)] is the most nephrotoxic chemotherapeutic drug, discovered over four decades ago. Nephrotoxicity is the major side effect that limits the dose of cisplatin that can be safely administered, and it is a clinical problem in cancer patients who receive cisplatin combination chemotherapy. grace locker marshWebDiabetic nephropathy is characterized by inflammation, fibrosis, and oxidant stress, pathologic features that are shared by many other … grace locks ltdWebAug 1, 2007 · Cisplatin nephrotoxicity primarily causes tubulo-interstitial lesions. In animal models cisplatin damages the proximal tubules, specifically the S3 segment of the outer medullary stripe. Mitochondrial swelling and nuclear pallor occur in the distal nephron. The glomerulus has no obvious morphologic changes.49., 56., 59. chilling adventures of sabrina clothesWebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. Cisplatin has been associated with a low rate of serum enzyme elevations and with rare cases of clinically apparent, acute liver injury. chilling adventures of sabrina cast theo